Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

A quantitative description of membrane current and its application to conduction and excitation in nerve

A. L. Hodgkin, A. F. Huxley · The Journal of Physiology · 1952 · 23.2K citations · Full text

Natural Sciences, Biophysics, Physiology +12

A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.

C H Luo, Yoram Rudy · Circulation Research · 1994 · 1.6K citations

Natural Sciences, Biophysics, Physiology +17

Molecular mechanism for an inherited cardiac arrhythmia

Paul B. Bennett, Kazuto Yazawa, Naomasa Makita et al. · Nature · 1995 · 967 citations

Medicine, Cardiology, Molecular Genetics +13

Long QT Syndrome Patients With Mutations of the <i>SCN5A</i> and <i>HERG</i> Genes Have Differential Responses to Na ⁺ Channel Blockade and to Increases in Heart Rate

Peter J. Schwartz, Silvia G. Priori, Emanuela H. Locati et al. · Circulation · 1995 · 816 citations

Medicine, Cardiology, Pharmacology +16

A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation.

C H Luo, Yoram Rudy · Circulation Research · 1994 · 466 citations · Full text

Medicine, Cardiology, Physiology +17