DRUG-INDUCED PEPTIC ULCER

Abstract

Article1 October 1957DRUG-INDUCED PEPTIC ULCERJOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.JOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-4-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe not infrequent occurrence of peptic ulcer in man is perhaps not surprising, considering that the digestive tract, from early life, is subjected to innumerable mechanical, bacterial, chemical, thermal, physiologic, endocrinologic, neurogenic and psychogenic influences.1The relative significance of these factors in the development of peptic ulcer is difficult to assess; each undoubtedly is important. Individual susceptibility also plays a decisive, albeit mysterious rôle, else the incidence of peptic ulcer would greatly exceed the usual estimate of 5 to 10%.2The tendency of certain therapeutic agents to induce gastroduodenal ulceration represents another, increasingly important cause of peptic ulcer in...Bibliography1. KirsnerPalmer JBWL: The problem of peptic ulcer, Am. J. Med. 13: 615, 1952. CrossrefMedlineGoogle Scholar2. IvyGrossmanBachrach ACMEWH: Peptic ulcer, 1950, The Blakiston Co., Philadelphia. Google Scholar3. McCann JC: Experimental peptic ulcer, Arch. Surg. 19: 600, 1929. CrossrefGoogle Scholar4. Selye H: The general adaptation syndrome and peptic ulcer, in Peptic ulcer, Sandweiss, D. J., Editor, 1951, W. B. Saunders Co., Philadelphia, p. 125. Google Scholar5. LamblingHardouinBonfilsLaumonier AJPSR: Ulcère gastrique expérimental, Arch. d. mal. de l'app. digestif. 42: 417, 1953. MedlineGoogle Scholar6. 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