Submucous rather than myenteric neurons are activated by mucosal biopsy supernatants from irritable bowel syndrome patients

Abstract

Direct neuronal activation by IBS mucosal biopsy supernatants is primarily a feature of submucous rather than myenteric neurons. This is associated with a stronger excitation of submucous neurons by serotonin. The plexus-specific effects support the concept that altered mucosa-nerve signaling underlies disturbances in IBS.