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A Hepatitis Virus Complicating Studies With Mouse Leukemia
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1961
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Hepatic DisordersHepatologyMouse LeukemiaHepatic DiseaseViral HepatitisLiver PhysiologyMolecular VirologyHematologyImmunologyHepatitisVirologyPathologyViral PathogenesisStrain Balb/c MiceAdult T-cell Leukemia-lymphomaMedicineViral ImmunityHealth Sciences
Hepatitis was frequently observed in strain BALB/c mice during the course of studies with the Moloney murine leukemia virus. A virus isolated from mice with hepatic disease was propagated and quantitatively assayed by methods in vitro. The properties of this agent, designated MHV-A59, were detailed, and a relationship to one member of the established mouse “hepatoencephalitis” group of viruses was ascertained.