Synthesis of optically active .BETA.-methyltryptophans from aziridine-2-carboxylates. - Concepedia

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Synthesis of optically active .BETA.-methyltryptophans from aziridine-2-carboxylates.

DOI Full Paper Access

49

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0

References

1990

Year

Ichiro Shima, Norihiko Shimazaki, Keisuke Imai, Keiji Hemmi, Masashi Hashimoto

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryActive .Beta.-methyltryptophansBiochemistryNatural SciencesOrganic ChemistryStereoselective SynthesisChemistryHeterocycle ChemistrySynthetic ChemistryEnantioselective Synthesis

Abstract

Some (αR, βR) -1, β-dimethyltryptophans (5__∼) were prepared by the reaction of aziridine-2-carboxylates (4__∼), derived from D-threonine, and N-alkylindoles in the presence of BF3·OEt2.