Relationship of<i><scp>CYP3A5</scp></i>genotype and<i><scp>ABCB1</scp></i>diplotype to tacrolimus disposition in Brazilian kidney transplant patients

Abstract

CYP3A5 is the major enzyme responsible for the marked interindividual variability in TAC PK, but it cannot be considered alone when predicting dose adjustment because ABCB1 diplotypes also affect TAC disposition, showing independent and additive effects on the TAC dose-normalized concentration.