Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium.

Abstract

BMP-2 and BMP-4 may serve as negative growth regulators in the retina and RPE that are downregulated by injury, to allow tissue repair. Modulation of expression of the BMPs may provide a means to control the exaggerated wound repair that occurs in proliferative retinopathies.