Synthesis of Cyclic γ‐Amino Acids for Foldamers and Peptide Nanotubes

Abstract

Abstract Cyclic γ‐amino acids are molecular building blocks of great interest in peptide and foldamer chemistry, as they allow the preparation of new structures that are not found in Nature. In this paper, we describe the synthesis of cyclic γ‐amino acids that have a cis relationship between the amino and the carboxylic acid groups. This arrangement, in most cases, induces the resulting peptides to adopt a flat conformation, which makes them appropriate for the design of foldamers that adopt β‐sheet‐type structures.