Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Caseariasylvestris Sw.

Abstract

Casearins G-R, new cytotoxic clerodane diterpenes have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). Their structures have been elucidated by spectroscopic methods and chemical conversions, and their structure-activity relationships have been discussed.