QUINIDINE-INDUCED THROMBOCYTOPENIC PURPURA COMPLICATING DICUMAROL THERAPY

Abstract

Case Reports1 May 1955QUINIDINE-INDUCED THROMBOCYTOPENIC PURPURA COMPLICATING DICUMAROL THERAPYROBERT D. GITTLER, M.D., MILTON KISSIN, M.D., F.A.C.P., JOSEPH LITWINS, M.D., F.A.C.P.ROBERT D. GITTLER, M.D.Search for more papers by this author, MILTON KISSIN, M.D., F.A.C.P.Search for more papers by this author, JOSEPH LITWINS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-5-1118 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe allergic and toxic manifestations which may follow the use of quinidine are well known.1Such reactions may be classified as (1) gastrointestinal, (2) respiratory, (3) dermatologic, (4) renal, (5) neurologic, (6) hematopoietic, (7) febrile, and (8) combined forms. Gastrointestinal effects ascribed to quinidine are nausea, vomiting, abdominal distress and diarrhea; respiratory effects resemble a histamine reaction, with coryza and bronchospasm; dermatologic effects occur as pruritus, urticaria, angioneurotic edema, morbilliform, scarlatiniform and maculopapular rashes, exfoliative dermatitis, pigmentation, and eczematoid and pemphigoid lesions; renal effects are hematuria and albuminuria; cardiovascular toxic effects seen are ventricular fibrillation and asystole; hematopoietic effects include...Bibliography1. Brown EA: Drug allergy, Quart. Rev. Allergy and Appl. Immun. 7: 51-82 (Mar.) 1953. Google Scholar2. Broch OJ: Thrombopenic purpura after administration of quinidine, Nord. med. 10: 1542-1544, 1941. Google Scholar3. NudelmanLaffHowe PLILCD: Thrombocytopenic purpura following quinidine, J. A. M. A. 137: 1219, 1948. CrossrefMedlineGoogle Scholar4. Norcross JW: Quinidine as a cause of thrombocytopenic purpura, New England J. Med. 242: 53 (Jan. 12) 1950. CrossrefMedlineGoogle Scholar5. BigelowDesforges FSJF: Platelet agglutination by an abnormal plasma factor in thrombocytopenic purpura associated with quinidine ingestion, Am. J. M. Sc. 224: 274, 1952. CrossrefMedlineGoogle Scholar6. Larson RK: The mechanism of quinidine purpura, Blood 8: 16, 1953. CrossrefMedlineGoogle Scholar7. BoltonYoung FGRV: Observations on cases of thrombocytopenic purpura due to quinine, sulphamezathine and quinidine, J. Clin. Path. 6: 320 (Nov.) 1953. CrossrefMedlineGoogle Scholar8. BarkhamTocantins PLM: Thrombocytopenia due to hypersensitivity to quinidine, Blood 9: 2, 1954. CrossrefGoogle Scholar9. WaldWeinerSussman NMLN (a) : Investigation of coagulation defects using a modified prothrombin consumption test, Bull. New York Acad. Med. 28: 9, 1952. (b) Sussman, L. N., Cohen, I. B., and Gittler, R. D.: Clinical applications of the serum prothrombin consumption test, J. A. M. A. 156: 7, 1954. Google Scholar10. SussmanWaldRosenthal LNNRL: A hemorrhagic diathesis due to a qualitative platelet defect, Blood 7: 11, 1952. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication May 12, 1954.From the Medical and Laboratory Service, Beth Israel Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBIBLIOGRAPHYZwischenfälle bei ChinidinbehandlungQUINIDINE PURPURA: REPORT OF SIX CASES*RONALD C. BISHOP, M.D., F.A.C.P., HERBERT H. SPENCER, M.D., FRANK H. BETHELL, M.D., F.A.C.P.The Quinidine ProblemQuinidine Treatment of Auricular Fibrillation 1 May 1955Volume 42, Issue 5Page: 1118-1122KeywordsHeartHistamineLesionsNauseaPruritusRashesResearch laboratoriesUrticariaVentricular fibrillationVomiting ePublished: 1 December 2008 Issue Published: 1 May 1955 PDF downloadLoading ...