Müller cell outgrowth after retinal detachment: association with cone photoreceptors.

Abstract

The hypertrophy of Muller cells was readily traced using antibodies to vimentin and GFAP. When labeling with these antibodies was combined with labeling by either antibodies to cone opsins or biotinylated PNA, a consistent relationship was observed between the Müller cell processes growing through the OLM and cone photoreceptors. CONCLUSIONS. The growth of Müller cell processes into the subretinal space forms a fibrotic layer that completely inhibits the regeneration of outer segments. The current results show that there appears to be a highly specific interaction between growing Müller cell processes and cone photoreceptors during the earliest phase in this process.