Nociceptive phenotype of dorsal root ganglia neurons innervating the subchondral bone in rat knee joints

Abstract

The majority of sensory DRG neurons innervating the subchondral bone of the distal femur were CGRP-IR and TrkA-IR. It is expected that therapeutic approaches targeting CGRP and TrkA could be effective in attenuating pain from the subchondral bone in knee joints.