The pharmacokinetics of cyclophosphamide, phosphoramide mustard and nor‐ nitrogen mustard studied by gas chromatography in patients receiving cyclophosphamide therapy.

Abstract

1 Simple, accurate and specific gas-chromatographic methods for the estimation of derivatized phosphoramide and non-nitrogen mustards utilizing alkali-flame ionization detection are described. 2 The pharmacokinetics in plasma of cyclophosphamide, phosphoramide mustard, nor-nitrogen mustard and nitrobenzyl pyridine alkylating activity were investigated following administration of cyclophosphamide by intravenous and oral routes to patients with malignant disease 3 The mean T1 for cyclophosphamide was 8.88 h (s.d. 1.25 h) and the apparent volume of distribution (Vdfl) was 0.74 1 kg-1 (s.d. 0 .16 1 kg-1).