Novel coumarin modified <scp>GLP</scp>‐1 derivatives with enhanced plasma stability and prolonged <i>in vivo</i> glucose‐lowering ability

Abstract

Cysteine-specific coumarin conjugation with GLP-1 offers a useful approach to the development of long-acting incretin-based antidiabetic agents. Conjugate 7 is a promising long-lasting GLP-1 derivative deserving further investigation.