Clozapine, but not haloperidol, enhances glial<scp>d</scp>‐serine and L‐glutamate release in rat frontal cortex and primary cultured astrocytes

Abstract

Clozapine predominantly activated glial exocytosis of D-serine, and this clozapine-induced D-serine release subsequently enhances neuronal L-glutamate release via NMDA receptor activation. The enhanced D-serine associated glial transmission seems a novel mechanism of action of clozapine but not haloperidol.