The carcinogenicity of fluoro derivatives of 10-methyl-1,2-benzanthracene. I. 3- and 4'-Monofluoro derivatives.

Abstract

Summary Substitution of fluorine in the 3 position of the K region of 10-methyl-1,2-benzanthracene virtually abolished the carcinogenic activity of this hydrocarbon toward mouse skin and the subcutaneous tissues of rats and mice. Insertion of fluorine in the 49 position on the angular ring of the hydrocarbon produced a derivative highly toxic to rats and mice. No adequate tests of its carcinogenicity has been possible so far, although a single dose had moderate activity as an initiator of papillomas.