PENICILLIN AS A CHEMOTHERAPEUTIC AGENT

Abstract

Article1 November 1943PENICILLIN AS A CHEMOTHERAPEUTIC AGENTMARTIN H. DAWSON, GLADYS L. HOBBY, KARL MEYER, ELEANOR CHAFFEEMARTIN H. DAWSONSearch for more papers by this author, GLADYS L. HOBBYSearch for more papers by this author, KARL MEYERSearch for more papers by this author, ELEANOR CHAFFEESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-5-707 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1929, while examining plates seeded with staphylococci, Fleming1observed that colonies failed to grow in the neighborhood of a colony of a contaminating mold. Following up this chance observation, Fleming isolated the mold, identified it as a strain ofPenicillium notatum, and showed that it produced in broth cultures a soluble substance which exerted a remarkable inhibitory effect on pyogenic cocci and the diphtheria group of organisms but not on certain Gram negative rods. He designated the substance as penicillin and suggested that it might be used for differential diagnostic purposes in the cultivation of Gram positive and Gram...Bibliography1. FLEMING A: On antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae , Brit. Jr. Exper. Path., 1929, x, 226. Google Scholar2. CLUTTERBUCKLOVELLRAISTRICK PWRH: The formation from glucose by members of the Penicillium chrysogenum series of a pigment, and alkali-soluble protein and penicillin—the antibacterial substance of Fleming, Biochem. Jr., 1932, xxvi, 1907. CrossrefGoogle Scholar3. CHAIN E: Penicillin as a chemotherapeutic agent, Lancet, 1940, ii, 226. CrossrefGoogle Scholar4. DUBOS RJ: Studies on a bactericidal agent extracted from a soil bacillus. I. Preparation of the agent. Its activity in vitro, Jr. Exper. Med., 1939, lxx, 1. CrossrefGoogle Scholar5. ABRAHAMFLOREY EPHW: Further observations on penicillin, Lancet, 1941, ii, 177. CrossrefGoogle Scholar6. MEYER K: On penicillin, Science, 1942, lxxxxvi, 20. CrossrefGoogle Scholar7. HOBBYMEYERCHAFFEE GLKE: Activity of penicillin in vitro, Proc. Soc. Exper. Biol. and Med., 1942, l, 277. CrossrefGoogle Scholar8. HOBBYMEYERCHAFFEE GLKE: Observations on the mechanism of action of penicillin, ibid., 1942, l, 281. Google Scholar9. HOBBYMEYERCHAFFEE GLKE: Chemotherapeutic activity of penicillin, ibid., 1942, l, 285. Google Scholar10. MEYERHOBBYCHAFEE KGLE: On esters of penicillin, Science, 1943, lxxxxvii, 205. CrossrefGoogle Scholar11. MEYERHOBBYDAWSON KGLMH: Chemotherapeutic activity of esters of penicillin, Proc. Soc. Exper. Biol., and Med., 1943, liii, 100. CrossrefGoogle Scholar12. ALEXANDER H: Response to antiserums in meningococcic infections of human beings and mice, Am. Jr. Dis. Child., 1939, lviii, 746. CrossrefGoogle Scholar13. THYGESEN P: Personal Communication. Google Scholar14. RAMMELKAMPKEEFER CHCS: The absorption, excretion, and toxicity of penicillin administered by intrathecal injection, Am. Jr. Med. Sci., 1943, ccv, 342. CrossrefGoogle Scholar15. RAMMELKAMPKEEFER CHCS: The absorption, excretion, and distribution of penicillin, Jr. Clin. Invest., 1943, xxii, 425. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*The material contained in this communication was presented for the most part in a paper delivered before the American College of Physicians at St. Paul, in April 1942. Received for publication June 11, 1943.From the Departments of Medicine and Ophthalmology, College of Physicians and Surgeons, Columbia University, The Edward Daniels Faulkner Arthritis Clinic and the Institute of Ophthalmology, Presbyterian Hospital, New York.This work has been supported in part by a grant from the John and Mary Markle Foundation. 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