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Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full <i>in vitro</i> analysis

Timothy D. Warner, Francesco Giuliano, Ivana Vojnovic et al. · Proceedings of the National Academy of Sciences · 1999 · 1.5K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +12

Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin

Francesca Catella-Lawson, Muredach P. Reilly, Shiv Kapoor et al. · New England Journal of Medicine · 2001 · 1.4K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Coxibs and Cardiovascular Disease

Garret A. FitzGerald · New England Journal of Medicine · 2004 · 896 citations

Medicine, Medicinal Chemistry, Pharmacology +15