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Erythro-Selective Aldol Reaction of Tricarbonyl(.ETA.6-o-trialkylsilylbenzaldehyde)chromium(0) Complexes with Cyclic Ketene Silyl Acetals.
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1991
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Inorganic ChemistryEngineeringBiochemistryFive-membered AcetalNatural SciencesOrganometallic ElectrochemistryOrganic ChemistryErythro SelectivityOrganometallic CatalysisErythro-selective Aldol ReactionStereoselective SynthesisChemistryAsymmetric CatalysisEnantioselective SynthesisOrtho Tms Group
The aldol reaction of tricarbonyl(o-trimethylsilyl(TMS)-benzaldehyde)chromium(0) complex (1a) with cyclic ketene silyl acetals (2-4) afforded the corresponding erythro products selectively. Changing the ortho TMS group to a triisopropylsilyl (TIPS) group in the complex brought about an improvement of the erythro selectivity in the case of the five-membered acetal (4).