Elucidation of the Pathogenic Mechanism of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy by Proteomic Analysis

Abstract

1D-SDS-PAGE coupled with RP-LC-MS/MS is a valuable resource to aid in the characterization of the proteome of RRD patients with PVR. Inflammation is the important pathologic process of PVR, while complement and coagulation cascade was the crucial pathway. p53 and E2F1 may be the new targets for successful treatment of RRD with PVR.