Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa^®: toward target‐controlled infusion of volatiles into the breathing system

Abstract

The predictive performance of the two-compartment model was similar to that of models accepted for TCI administration of intravenous anesthetics, supporting open-loop administration of sevoflurane with the AnaConDa. Further studies will focus on prospective testing and external validation of the model implemented in a target-controlled infusion device.