Reduced Purkinje Cell Number in Essential Tremor

Abstract

Clinical and functional imaging evidencesuggests that cerebellar dysfunction occurs in essentialtremor (ET). In recent postmortem studies, we docu-mentedincreasednumbersoftorpedoes(Purkinjecellaxo-nal swellings) in ET patients without Lewy bodies. Pur-kinjecellloss,however,hasneverbeenrigorouslyassessed.