IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN: A DOUBLE-BLIND STUDY

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Article1 February 1960IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN: A DOUBLE-BLIND STUDYE. BEUTLER, M.D., S. E. LARSH, M.D., C. W. GURNEY, M.D.E. BEUTLER, M.D., S. E. LARSH, M.D., C. W. GURNEY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-378 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe chronically fatigued patient represents one of the most common and most challenging clinical problems faced by the physician today. Sometimes, clear-cut abnormalities revealed by the physical or laboratory examination point to an explanation of the patient's symptoms. More often, however, no clue to the nature of the patient's disorder is found. Consequently, the origin of the complaint is frequently relegated to the vague area of the psychoneuroses, sometimes unfortunately, in the absence of any positive evidence of emotional disturbance.Recent observations of Jasinski and co-workers1-5have drawn our attention to the possibility that some chronically fatigued women may be...Bibliography1. Jasinski B: Über Pathogenesis and Therapie der nicht-anämischen und leicht anämischen Eisenmangelzustande, Schweiz. med. Wchnschr. 79: 1255-1258, 1949. MedlineGoogle Scholar2. Jasinski B: Die Bedeutung der Eisenresorptionsversuche für die Diagnose und Differentialdiagnose der Eisenmangelanämien insbesondere für die Erkennung der Eisenmangelzustande ohne Anämie, Schweiz. med. Wchnschr. 79: 291-293, 1949. MedlineGoogle Scholar3. Jasinski B: Zur Frage der nicht- und der leicht anämischen Eisenmangelkrankheit, Praxis 38: 811-816, 1950. Google Scholar4. JasinskiDiener BE: Zur Frage der Häufigkeit des larvierten Eisenmangels bei Frauen, insbesondere bei graviden und bei wochnerinnen, Gynaecologia 133: 293-304, 1952. MedlineGoogle Scholar5. JasinskiRoth BO: Larvierte Eisenmangelkrankheit, 1954, Benno Schwabe and Co., Basel. Google Scholar6. BecquerelRodier LA: Gaz. med. Paris 12: 751, 1844, cited by Berde, B., Hollander, L., Undritz, E., and Zehnder, K.: Serumeisenstudien bei Blutspendern, Schweiz. med. Wchnschr. 85: Nr. 38/39, 936, (Sept. 20) 1955, by Undritz, E., in discussion. Google Scholar7. Laache S: Die Anämie, 1883, Malling, Christiania, Norway. Google Scholar8. Sahli H: Lehrbuch der klinischen Untersuchungsmethoden, 1908, Franz Deuticke, Leipzig and Vienna, p. 933. Google Scholar9. Dubnikoff D: Klinische Untersuchungen über Eisenwirkung und "larvierte Chlorose." Ein Beitrag zur Lehre von der Chlorose, Inaugural Dissertation, 1908, Stampfli et Cie., Bern, Switzerland. Google Scholar10. Naegeli O: Blutkrankheiten und Blutdiagnostik (Lehrbuch der morphologischen Hämatologie), 1908, Verlag Von Veit and Company, Leipzig, p. 237. CrossrefGoogle Scholar11. Morawitz P: Untersuchungen über Chlorose, München. med. Wchnschr. 57: 1425-1430, 1910. Google Scholar12. Beifeld AF: Chlorosis, M. Clin. Chicago 2: 963-989, 1916-1917. Google Scholar13. Waldenström J: Iron and epithelium. Some clinical observations, Acta med. Scandinav. Suppl. 90: 380-397, 1938. Google Scholar14. Rustung E: Studies on serum iron, Acta dermat.-venereol. Suppl. 21 (Oslo) 29: 1-140, 1949. Google Scholar15. Thedering F: Diagnose und Behandlung des larvierten Eisenmangels, Med. Klin. 50: 1463-1467, 1950. Über die Steuerung der Eisenresorption, Medizinische 38: 1224-1228 (Sept. 19), 1953. Google Scholar16. GoldeckRemyLabhard HDH: Eisenmangel und Schwangerschaft, Deutsche med. Wchnschr. 79: 211-212, 1954. CrossrefMedlineGoogle Scholar17. Undritz E: Die larvierte Chlorose von Sahli, Schweiz. Naturforsch. Gesells. Verhandl. 136: 169-170, 1956. Google Scholar18. VerloopMeeuwissenBlokhuis MCJEEW: Comparison of the "iron absorption test" with the determination of the iron-binding capacity of serum in the diagnosis of iron deficiency, Brit. J. Haemat. 4: 70-81, 1958. CrossrefMedlineGoogle Scholar19. Beutler E: The clinical evaluation of iron stores, New England J. Med. 256: 692-697, 1957. CrossrefMedlineGoogle Scholar20. BeutlerRobsonButtenwieser EME: A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores, Ann. Int. Med. 48: 60-82, 1958. LinkGoogle Scholar21. Beutler E: Iron enzymes in iron deficiency. I. Cytochrome C, Am. J. M. Sc. 234: 517-527, 1957. CrossrefMedlineGoogle Scholar22. BeutlerBlaisdell ERK: Iron enzymes in iron deficiency. III. Catalase in rat red cells and liver with some further observations on cytochrome C, J. Lab. and Clin. Med. 52: 694-699, 1958. MedlineGoogle Scholar23. Beutler E: Iron enzymes in iron deficiency. IV. Cytochrome oxidase in rat kidney and heart, Acta haemat. 21: 371-377, 1959. CrossrefMedlineGoogle Scholar24. Beutler E: Iron enzymes in iron deficiency. V. Succinic dehydrogenase in rat liver, kidney and heart, Blood, in press. Google Scholar25. Beutler E: Iron enzymes in iron deficiency. VI. Aconitase activity and citrate metabolism, J. Clin. Investigation 38: 1605-1616, 1959. CrossrefMedlineGoogle Scholar26. GublerCartwrightWintrobe CJGEMM: Studies on copper metabolism. XX. Enzyme activities and iron metabolism in copper and iron deficiencies, J. Biol. Chem. 224: 533-546, 1957. CrossrefMedlineGoogle Scholar27. KampschmidtAdamsGoodwin RFMEWL: Cytochrome C concentration in the tissues of normal and tumor-bearing rats, Arch. Biochem. and Biophys. 82: 42-49, 1959. CrossrefMedlineGoogle Scholar28. BeutlerBlaisdell ERK: Iron enzymes in iron deficiency. II. Catalase in human erythrocytes, J. Clin. Investigation 37: 833-835, 1958. CrossrefMedlineGoogle Scholar29. Boddington MM: Changes in buccal cells in the anaemias, J. Clin. Path. 12: 222-227, 1959. CrossrefMedlineGoogle Scholar30. Jacobs A: Oral cornification in anaemic patients, J. Clin. Path. 12: 234-237, 1959. CrossrefGoogle Scholar31. HussainPatwardban RVN: Iron content of thermal-sweat in iron-deficiency anemia, Lancet 1: 1073-1074 (May 23) 1959. CrossrefMedlineGoogle Scholar32. BarkanWalker GBS: Determination of serum iron and pseudohemoglobin iron with O-phenanthroline, J. Biol. Chem. 135: 37-42, 1940. CrossrefGoogle Scholar33. RathFinch CGCA: Chemical, clinical, and immunological studies on the products of human plasma fractionation. XXXVIII. Serum iron transport. Measurement of iron-binding capacity of serum in man, J. Clin. Investigation 28: 79-85, 1949. CrossrefGoogle Scholar34. KaplanZuelzerMouriquand EWWC: Sideroblasts. A study of stainable nonhemoglobin iron in marrow normoblasts, Blood 9: 203-213, 1954. CrossrefMedlineGoogle Scholar35. Fisher RA: The exact treatment of 2 X 2 tables, in Statistical methods for research workers, 12th Ed., 1954, Hafner Publishing Co., Inc., New York, pp. 96-97. Google Scholar36. Heilmeyer L: Zur Frage der Reizwirkung des Eisens, Deutsche med. Wchnschr. 75: 1086, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication August 7, 1959.From the Argonne Cancer Research Hospital, operated by The University of Chicago for the United States Atomic Energy Commission, and the Department of Medicine, The University of Chicago, Chicago, Illinois.Requests for reprints should be addressed to Ernest Beutler, M. D., Chairman, Department of Medicine, City of Hope Medical Center, Duarte, California. 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BOWMAN JR., M.D.Studies in iron metabolismRefractory anemias of pregnancy 1 February 1960Volume 52, Issue 2Page: 378-394KeywordsAnemiaAttentionBlood plasmaEmotionsHemoglobinHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...