A mammalian ortholog of <i>Drosophila timeless</i>, highly expressed in SCN and retina, forms a complex with mPER1

Abstract

We have reported the isolation of the mouse timeless cDNA, the expression of the mTim mRNA and an interaction of mTIM with mPER1. These results indicate that the autoregulatory feedback mechanism of circadian oscillation of the period gene may also be conserved in mammals.