Dysregulation of CD4+CD25^high T Cells in the Synovial Fluid of Patients With Antibiotic‐Refractory Lyme Arthritis

Abstract

Patients with antibiotic-refractory Lyme arthritis often have lower frequencies of Treg cells, higher expression of activation coreceptors, and less effective inhibition of proinflammatory cytokines. This suggests that immune responses in these patients are excessively amplified, leading to immune dysregulation and antibiotic-refractory arthritis.