ADRENAL INFLUENCES ON THE STOMACH: PEPTIC ULCER IN ADDISON'S DISEASE DURING ADRENAL STEROID THERAPY

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Article1 July 1956ADRENAL INFLUENCES ON THE STOMACH: PEPTIC ULCER IN ADDISON'S DISEASE DURING ADRENAL STEROID THERAPYSEYMOUR J. GRAY, M.D., Ph.D., F.A.C.P., COLIN G. RAMSEY, M.D., GEORGE W. THORN, M.D., F.A.C.P.SEYMOUR J. GRAY, M.D., Ph.D., F.A.C.P.Search for more papers by this author, COLIN G. RAMSEY, M.D.Search for more papers by this author, GEORGE W. THORN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-73 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA relationship between the adrenal gland and the stomach has been demonstrated by an increased gastric acid and pepsin secretion during adrenal stimulation. The adrenal gland has been implicated in the pathogenesis of peptic ulcer disease by the development or reactivation of peptic ulcer during the administration of ACTH or the adrenal steroids.1-5 Conversely, patients with adrenal hypofunction (Addison's disease) characteristically present a decrease in gastric acidity and an unusually low incidence of chronic peptic ulcer.It has been postulated that emotional duress and other alarm stimuli may produce acute and chronic peptic ulcer in man by a hypothalamic-pituitary-adrenal pathway...Bibliography1. GraySpiroReifenstein SJHMRW: ACTH and gastrointestinal enzymes. Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 177-183. Google Scholar2. GrayBensonReifensteinSpiro SJJARWHM: Chronic stress and peptic ulcer, J. A. M. A. 147: 1529, 1951. CrossrefMedlineGoogle Scholar3. 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Endocrinol. and Metabolism 15: 1300, 1955. CrossrefGoogle Scholar34. Selye H: Physiology and pathology of exposure to stress. Treatise based on concepts of general adaptation, 1950, Acta, Inc., Montreal, p. 688. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 23, 1956.From the Medical Clinic, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts.This work was supported in part by the United States Public Health Service, the John A. Hartford Foundation, and the Gastrointestinal Fund of the Peter Bent Brigham Hospital, Boston, Massachusetts.Requests for reprints should be addressed to Seymour J. Gray, M.D., Peter Bent Brigham Hospital, Boston, Massachusetts. 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KIRSNER, M.D., Ph.D., F.A.C.P.Indirect gastric secretory studies“Stress” Ulceration of the Gastrointestinal Tract 1 July 1956Volume 45, Issue 1Page: 73-87KeywordsAdrenal glandsAdrenocorticotropic hormoneExcretionGlucocorticoid therapyMedical servicesPathogenesisPepsinsPeptic ulcersSteroid therapyStomach ePublished: 1 December 2008 Issue Published: 1 July 1956 PDF downloadLoading ...