Control of enteric neuromuscular functions by purinergic A₃receptors in normal rat distal colon and experimental bowel inflammation

Abstract

Normally, adenosine modulated colonic cholinergic motility via activation of A(3) receptors in the myenteric plexus. A(3) receptor-mediated tonic inhibitory control by adenosine was impaired in inflamed bowel, despite increased density of functioning and pharmacologically recruitable A(3) receptors.