Critical Care · 2004 · 259 citations · 38 references
MedicineHematologySurgeryHemostasisPostoperative Critical CareTransfusion MedicineAnticoagulant TherapyBlood Transfusion ManagementCoagulation AbnormalitiesHemostasis ManagementHemostatic AgentsPostoperative Bleeding ControlCoagulationFactor ViiaHemostatic Agent UseHemostatic Agents In SurgeryIntraoperative Bleeding ControlPharmacologic Hemostatic AgentsPostoperative HemostasisRecombinant Activated Factor Vii
Recombinant factor VIIa (rFVIIa) is a prohaemostatic agent that has successfully been used for the treatment of patients with haematological malignancies and coagulopathy. It also has been used in postsurgical patients where the coagulopathy in combination with hypothermia and metabolic acidosis causes an increase of mortality early post operation. Recently reported has been the use of rFVIIa in patients with a normal coagulation system, undergoing major surgery in order to reduce the intraoperative bleeding and the need for transfusions. Here we present our experience on rFVIIa use in ICU patients.
38