Adsorptive behaviour and voltammetric analysis of propranolol at carbon paste electrode

Abstract

Electrochemical oxidation of propranolol has been studied in Britton-Robinson buffer over the pH range: 2.0-11.0 at carbon paste electrode using cyclic, linear sweep and differential pulse voltammetry. A well-defined adsorptive anodic peak was obtained at 0.918 V (vs Ag-AgCl) at pH 2.0. A linear calibration range of 6.0 x 10 - 7 -5.0 × 10 - 5 mol L - 1 and detection limit of 2.0 × 10 - 7 mol L - 1 for propranolol were found using anodic adsorptive stripping differential pulse voltammetry. The proposed voltammetric approach has been applied to the determination ofthe drug in tablet dosage form. The results were statistically consistent with those obtained with the reference UV method.