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CYP2E1 mediated isoniazid-induced hepatotoxicity in rats.

127

Citations

6

References

2004

Year

Jiang Yue, Ren-xiu Peng, Jing Yang, Rui Kong, Juan Liu
PubMed

Abstract

The metabolite of INH, hydrazine, plays an important role in INH-induced hepatotoxicity in rats. The induction of CYP2E1 by hydrazine is involved in the hepatotoxicity of INH. RFP does not exacerbate INH-induced hepatotoxicity in short term, which relates to down-regulation of CYP2E1.

References

YearCitations

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