Two modes of activation of the permeability transition pore: The role of mitochondrial cyclophilin

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

Valeria Petronilli, Paola Costantini, Luca Scorrano et al. · Journal of Biological Chemistry · 1994 · 532 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

Annamaria Nicolli, Emy Basso, Valeria Petronilli et al. · Journal of Biological Chemistry · 1996 · 483 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

Paolo Bernardi · Journal of Biological Chemistry · 1992 · 457 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

Valeria Petronilli, Carmen Cola, Stefano Massari et al. · Journal of Biological Chemistry · 1993 · 318 citations · Full text

Life Sciences, Biophysics, Physiology +17

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

Richard K. Harrison, Ross L. Stein · Biochemistry · 1990 · 304 citations

Life Sciences, Biochemistry, Molecular Biology +15