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Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids. II.
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1988
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Molecular PharmacologyMedicinal ChemistryPolyphenolicsBiochemistryNatural SciencesMedicinePhytochemistryMechanism Of ActionOther FlavonoidsPhytopharmacologyPhytochemicalSixty-one FlavanonesChemical BiologyPharmacologyInhibitory ActivityProtein PhosphorylationDrug Discovery
Sixty-one flavanones, twenty-six isoflavones and eight other flavonoids, obtained from Sophora tomentosa, S. flavescens, Scutellaria baicalensis and other medicinal plants or synthesized, were tested for their inhibitory activity against adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase from beef heart. The structure-activity relationships were investigated.