<scp>PKPD</scp>modelling of the interrelationship between mean arterial<scp>BP</scp>, cardiac output and total peripheral resistance in conscious rats

Abstract

A system-specific model characterizing the interrelationship between BP, CO and TPR was obtained, which can be used to quantify and predict the cardiovascular effects of a drug and to elucidate the MoA for novel compounds. Ultimately, the proposed PKPD model could be used to predict the effects of a particular drug on BP in humans based on preclinical data.