The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119

Abstract

Activation of GPR119 is not required to mediate the cytoprotective actions of OEA in BRIN-BD11 or INS-1E cells. Rather, OEA is internalised and subjected to hydrolysis by FAAH to release free oleate, which then mediates the cytoprotection.