Chemical and Pharmaceutical Bulletin · 1990 · 32 citations · 2 references
Natural SciencesBiochemistryChemistryBiocatalysisNatural Product BiosynthesisOrganic ChemistryMicrobial Natural Product BiosynthesisOrganic SynthesisEnzymatic SynthesisNatural Product SynthesisNatural Product Total Synthesis
(+)-Indolmycenic ester 4, a key intermediate for the synthesis of (-)-indolmycin (1), was prepared from (2S, 3R)-epoxybutyrate 5 via (2S, 3S)-2-hydroxy-3-chlorobutyrate 6 or (2R, 3R)-2-mesyloxy-3-hydroxybutyrate 12, which were obtained by lipase-catalyzed kinefic resolution of the corresponding 2-acetates.
2