Extracellular matrix is modulated in advanced glycation end products milieu via a <scp>RAGE</scp> receptor dependent pathway boosted by transforming growth factor‐<i>β</i>1 在晚期糖基化终末产物环境中细胞外基质通过RAGE受体依赖性途径调节，转化生长因子‐<i>β</i>1可以促进这种调节

Abstract

Although AGEs regulate RAGE and TGF-β1 by distinct pathways, RAGE activation leads to a further increase of TGF-β1 levels. MMP-2 activity seems to rely on TGF-β1, while MMP-9 was dependent on RAGE. These factors converge to control collagen IV turnover. Furthermore, although the antibody treatments might appear more efficient than AG in decreasing collagen IV levels, the cells compensate the RAGE and TGF-β1 blockade by increasing the mRNA expression of these proteins.