MedicineEndocrinologyToxicologyReproductive BiologyReproductive EndocrinologySteroid BiochemistryMale Reproductive EndocrinologyReproductive PharmacologySteroid PharmacologyTesticular FunctionTesticular PhysiologyTesticular ToxicologyExtractSteroidogenic RegulationTesticular BiochemistryTesticular Function AssessmentTesticular HormonesTesticular Steroid SynthesisTesticular Steroidogenesis RegulationTestosterone Suppression
The aqueous extract of leaf of Aegle marmelos (Bael) at the dose 50 mg/100 g body weight resulted a significant diminution in the activities of key testicular steroidogenic enzymes along with low levels of plasma testosterone and relative wet weights of sex organs in respect to control without any significant alteration in general body growth. Germ cells numbers in different generation at stage VII of seminiferous epithelial cell cycle were diminished significantly after the treatment of the above extract. The above mentioned dose did not exhibit any toxicity in liver and kidney. Therefore, it may be predicted that the aqueous extract of leaf of Aegle marmelos has a potent antitesticular effect at a specific dose.
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Estimation of nuclear population from microtome sections
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