EVALUATION OF IMMUNOMODULATORY POTENTIAL' OF EMBLICA OFFICINALIS FRUIT PULP EXTRACT IN MICE

Abstract

Aqueous extract of dried Emblica officinalis Gaertn. (Amla) fruit pulp powder was evaluated for immunomodulatory effect on male Swiss Albino mice. The mice were divided into three groups. The first group received vehicle alone to serve as control. The second and third groups received the extract orally at 100 and 200 mg/kg body weight dose levels respectively per day for a period of 19 days. There was significant dose dependent increase in haemagglutination antibody titre, sheep red blood cells induced delayed type of hypersensitivity reaction, macrophage migration index, respiratory burst activity of the peritoneal macrophages, total leukocyte count, percentage lymphocyte distribution, serum globulin and relative lymphoid organ weight in Emblica treated mice indicating its ability to stimulate humoral as well as cell mediated immunity along with macrophage phagocyte.