PubMed · 1997 · 24 citations · 11 references
Open access
EducationPharmacotherapyPsychiatryGeriatric PsychiatryPsychopharmacologyPsychotherapyAntidepressant PharmacotherapyDepression ManagementDepression PharmacotherapyInterpersonal PsychotherapyPsychotherapy For Mood DisordersPsychotherapy For Older AdultsAcute Depression TreatmentAntidepressant ResponseCombination Drug TherapyInterpersonal Psychotherapy For DepressionInterpersonal TherapyMajor DepressionPsychotherapy With Older AdultsTreatment Protocol Evaluation
One hundred eighty subjects at least 60 years of age with recurrent unipolar major depression were recruited to participate in a depression treatment protocol. All patients received drug therapy with nortriptyline (NT) and interpersonal psychotherapy (IPT) with an experienced clinician. Acutely, 81% of subjects showed a full response to combined treatment. In the initial 127 subjects, the most common problem areas in therapy were role transition (41%), interpersonal disputes (34.5%), and grief (23%). Case vignettes are presented and discussed. The combination of IPT and NT showed a powerful antidepressant effect. IPT was readily adaptable to the needs of depressed elders.
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M. Hamilton · Journal of Neurology Neurosurgery & Psychiatry · 1960 · 32.6K citations · Full text
Charles F. Reynolds, Ellen Frank, J M Perel et al. · American Journal of Psychiatry · 1992 · 161 citations
NIH consensus conference. Diagnosis and treatment of depression in late life
JAMA · 1992 · 133 citations