Targeting mitochondrial cardiolipin and the cytochrome <i>c</i> /cardiolipin complex to promote electron transport and optimize mitochondrial <scp>ATP</scp> synthesis

Abstract

SS-31 selectively targeted cardiolipin and modulated its interaction with cytochrome c. SS-31 inhibited the cytochrome c/cardiolipin complex peroxidase activity while protecting its ability to serve as an electron carrier, thus optimizing mitochondrial electron transport and ATP synthesis. This novel class of cardiolipin therapeutics has the potential to restore mitochondrial bioenergetics for treatment of numerous age-related diseases.