Anti‐inflammatory, Analgesic and Antipyretic Effects of Glaucine in Rats and Mice

Abstract

Anti-inflammatory, analgesic and antipyretic activity of glaucine was studied in rats and mice, and compared with indomethacin. Glaucine (10–100 mg kg−1) was effective in suppressing carrageenan-induced paw oedema and lipopolysaccharide-induced fever in rats, and acetic acid-induced abdominal constriction in mice. Similar results were obtained with indomethacin (2.5 mg kg−1). Unlike indomethacin, which produced stomach lesions at doses of 10–20 mg kg−1 glaucine did not produce gastric ulcerations at doses up to 500 mg kg−1. These results indicate that glaucine has promising anti-inflammatory, analgesic and antipyretic activity without associated gastric damage.