Concepedia

Publication | Open Access

Recombinant human soluble thrombomodulin prevents peripheral <scp>HMGB</scp>1‐dependent hyperalgesia in rats

DOIFull Paper Access

38

Citations

29

References

2013

Year

Junichi Tanaka, Yukari Seki, Hiroyasu Ishikura, Maho Tsubota, Fumiko Sekiguchi, Kaoru Yamaguchi, Akira Murai, Takehiro Umemura, Atsufumi Kawabata
British Journal of Pharmacology

Abstract

These data suggest that peripheral HMGB1 causes hyperalgesia, and that rhsTM abolishes HMGB1-dependent hyperalgesia, providing novel evidence for therapeutic usefulness of rhsTM as an analgesic.

References

YearCitations

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