Publication | Open Access
The Requirement for the Fc Portion of Antibody in Antigen-Antibody Complex-Mediated Suppression
44
Citations
0
References
1978
Year
Immunocytochemical TechniqueHumoral ResponseImmunologyInnate ImmunityImmunotherapyFc PortionInflammationAutoantibodiesAntibody EngineeringFc PieceImmune Complex-induced SuppressionAllergyAutoimmune DiseaseAutoimmunityHumoral ImmunityAntibody ScreeningCell BiologyAntibody BiologyAntigen-antibody Complex-mediated SuppressionImmunoglobulin EMedicine
The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complex-mediated suppression.