SPECULATIONS AS TO THE THERAPEUTIC SIGNIFICANCE OF THE PENICILLIN BLOOD LEVEL

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Article1 February 1948SPECULATIONS AS TO THE THERAPEUTIC SIGNIFICANCE OF THE PENICILLIN BLOOD LEVELHARRY EAGLEHARRY EAGLESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-2-260 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. THE DIRECT BACTERICIDAL ACTION OF PENICILLINPenicillin is actively bactericidal in vitro1, 2, 3, 4, 5, 6, 7; and although the body's cellular or humoral defense mechanisms probably play a contributory rôle in vivo, that direct bactericidal action may be largely responsible for the therapeutic activity of the drug.The susceptibility of a given organism to penicillin may be defined in terms of three concentrations (figures 1 and 2; cf. also2, 6, 7). The first is that which suffices only to reduce the normal rate of multiplication, and is illustrated by curve 0.004 in figure 1 and point A...Bibliography1. 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Public Health Service and The Johns Hopkins School of Hygiene and Public Health, Baltimore 5, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntibiotics and traumaSusceptibility and resistance emergence studies with macrolidesMouse Subcutaneous Cotton Thread ModelDoes the Degree of Penicillin Susceptibility of Streptococcus pneumoniae Affect the Bactericidal Activity of Co-Amoxiclav Versus Oral Cephalosporins at Physiological Concentrations? 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MUSSELMANEffect of schedule of administration on the therapeutic efficacy of penicillinÜber die Wirkungsweise von Dibromsalicyl bei StaphylokokkenThe Role of Penicillin in Obstetrics**Presented, by invitation, at the Fifty-Ninth Annual Meeting of the American Association of Obstetricians, Gynecologists and Abdominal Surgeons, Hot Springs, Va., September 9 to 11, 1948.Recent Advances in the Chemotherapy of Surgical InfectionsSyphilisSerum Concentration Following the Oral Administration of Crystalline Procaine Penicillin G and Crystalline Sodium Penicillin G*Serum Concentrations Following Five Treatment Schedules with Procaine Penicillin in Oil with Aluminum Monostearate**Flo-Cillin “96” was supplied by Bristol Laboratories, Inc.Pneumococcal Pneumonia Treated with Aqueous Penicillin at Twelve-Hour IntervalsPenicillin Dosage and Blood LevelsNationwide results in the treatment of early syphilis with penicillin 1 February 1948Volume 28, Issue 2Page: 260-278KeywordsAttentionBloodDrugsHygieneMedical servicesPenicillinPrevention, policy, and public healthResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1948 PDF downloadLoading ...