Autocrine secretion of 15d‐<scp>PGJ₂</scp> mediates simvastatin‐induced apoptotic burst in human metastatic melanoma cells

Abstract

We characterized simvastatin-induced activation of the 15d-PGJ2 /FABP5 signalling cascades, which triggered an apoptotic burst in melanoma cells but did not affect primary human melanocytes. These data support the rationale for the pharmacological targeting of 15d-PGJ2 in metastatic melanoma.