Journal of the Sanitary Engineering Division · 1971 · 31 citations · 0 references
Life SciencesMicrobiologyToxicologyEnvironmental MicrobiologyMicrobial EcologyWastewater TreatmentFungal BiochemistryHeavy Metal ContaminationMetal ToxicityNickel ToxicologyWastewater MicrobiologyCompetitive InhibitionCompetitive Inhibition ModelingMichaelis-menten AnalysisMichaelis-menten SpecificityMicrobial Interactions In Treatment ProcessesNoncompetitive InhibitionSubstrate ConditionsWaste Activated Sludge
The Michaelis-Menten model of enzyme inhibition is a convenient method to measure toxicity and to give insights to toxic behavior in pure culture and simple substrate conditions. A linear noncompetitive inhibition pattern is demonstrated for sewage bacteria and a linear competitive inhibition pattern for sewage fungus Geotrichum candidum. Silver and nickel are more toxic to sewage bacteria than to Geotrichum candidum and therefore the metal toxicity is believed to be connected with the overgrowth of the fungus in activated sludge processes.