Fungal Metabolites. XVI. Structures of New Peptaibols, Trichokindins I-VII, from the Fungus Trichoderma harzianum.

Abstract

New peptaibols, trichokindins I-VII, have been isolated from the fungus Trichoderma harzianum. Their structures were characterized by spectrometric methods. Trichokindins, which are 18-residue peptides containing one to three isovaline residues, were found to induce Ca(2+)-dependent catecholamine secretion from bovine adrenal medullary chromaffin cells.