SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASE

Abstract

Article1 June 1951SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASEMENARD M. GERTLER, STANLEY M. GARN, SAMUEL A. LEVINE, F.A.C.P.MENARD M. GERTLER, STANLEY M. GARN, SAMUEL A. LEVINE, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-6-1421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disease most frequently associated with an abnormal uric acid metabolism is gout.1, 2This association is based upon deposits of uric acid in the joints and connective tissue of gouty patients, usually in the presence of hyperuricemia.3While the etiologic factors are unknown, it is generally agreed that the hyperuricemia is caused by endogenous factors in lieu of exogenous or renal factors. Additional observations which complicate the picture are: (a) the gouty diathesis may be present with4or without5an increase in the level of serum uric acid; (b) hyperuricemia occurs in families where gout has not been recognized.6...Bibliography1. BauerKlemperer WF: Gout, in Duncan, Diseases of metabolism, 2nd Ed., 1947, Chapter XII: 611-656 (Reprint). Google Scholar2. Jacobson BM: The uric acid in the serum of gouty and of non-gouty individuals: its determination by Folin's recent method and its significance in the diagnosis of gout, Ann. Int. Med. 11: 1277-1294, 1938. LinkGoogle Scholar3. Garrod AB: Observations on certain pathological conditions of the blood urine in gout, rheumatism and Bright's disease, Med. Chir. Tr. London 31: 83, 1848. CrossrefMedlineGoogle Scholar4. Roberts W: Allbutt's System of medicine, 1st Ed., 1900, The Macmillan Co., New York. Google Scholar5. PetersVan Slyke JPDD: Quantitative clinical chemistry, 2nd Ed., 1946, vol. 8, Williams & Wilkins, Baltimore, p. 1041. Google Scholar6. SmythCottermanFreyberg CJCWRH: The genetics of gout and hyperuricemia—an analysis of nineteen families, J. Clin. Investigation 27: 749-759, 1948. CrossrefGoogle Scholar7. Scudamore C: A treatise on the nature and cure of gout, 4th Ed., 1823, Longman, Hurst, Rees, Orme and Brown, London. Google Scholar8. Futcher TB, in Osler, W., and McCrae, T.: Modern medicine, Vol. I, 1st Ed., 1907, chapter 31, Lea Bros., Philadelphia and New York, pp. 808-844. Google Scholar9. Huchard H: Traite clinique des maladies du coeur et de l'aorta, 1st Ed., 1899, G. Doin, Paris, p. 174. Google Scholar10. Folin O: Standardized methods for determination of uric acid in unlaked blood and urine, J. Biol. Chem. 101: 111-125, 1933. CrossrefGoogle Scholar11. ArkinColton HRR: An outline of statistical methods, 4th Ed., 1939, Barnes & Noble, Inc., New York, p. 224. Google Scholar12. SheldonStevensTucker WHSSWB: The varieties of human physique, 1st Ed., 1940, chapter 12, Harper & Bros., New York, p. 347. Google Scholar13. Mainland D: The treatment of clinical and laboratory data, 1st Ed., 1938, Oliver and Boyd, London, p. 340. Google Scholar14. Leary T: Crystalline ester cholesterol and atherosclerosis, Arch. Path. 47: 1-28, 1949. Google Scholar15. Hueper WC: Prevention and treatment of atherosclerosis, M. Clin. North America 33: 771-781, 1949. Google Scholar16. GertlerGarn MMSM: The lipid interrelationship in health and in coronary artery disease, Science 112: 14-16, 1950. CrossrefMedlineGoogle Scholar17. Brøchner-Mortensen K: Diagnosis of gout, Acta med. Scandinav. 99: 538-562, 1939. CrossrefGoogle Scholar18. AdlersbergParetsBoas DADEP: Genetics of atherosclerosis, J. A. M. A. 141: 246-254, 1949. CrossrefMedlineGoogle Scholar19. GertlerGarnLerman MMSMJ: The interrelationship of serum cholesterol, cholesterol esters and phospholipids in health and in coronary artery disease, Circulation 2: 205-214, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 1, 1950.From the Coronary Research Project, Massachusetts General Hospital and Harvard Medical School, Drs. P. D. White, H. B. Sprague, E. F. Bland, J. Lerman, S. A. Levine and E. A. Hooton, Directors. Supported by a grant from the Commonwealth Fund, New York City. 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A study based on a population survey in Hisayama town, Kyushu, JapanSerum uric acid: Correlation with biochemical, anthropometric, clinical and behavioral parameters in 10,000 israeli menUric acid: a risk factor for coronary heart disease?Prevalence and incidence of the diagnosis of gout in Great Britain.A prospective study of gout in New Zealand Maoris.Abnormal Urate Excretion Associated with Renal and Systemic Disorders, Drugs, and ToxinsEpidemiology of serum uric acid among 8000 Japanese-American men in HawaiiEffects of Diuretics On Lipid Metabolism in Patients With Essential HypertensionUraemia and hyperuricaemia in acute myocardial infarctionSerum uric acid: Its association with other risk factors and with mortality in coronary heart diseaseThe Epidemiology of Hyperuricemia and GoutKlinische Wertigkeit der Hyperuricämie. 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