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Promethazine-HCl as an Immunosuppressant
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1972
Year
ImmunohematologyHumoral Antibody SynthesisAllergy MedicineImmunodeficienciesHumoral ResponseImmunologyImmune RegulationPharmacotherapyImmune SystemImmunotherapyDrug AllergyHypersensitivityMedicinal ChemistryImmunochemistryAllergyAutoimmune DiseaseAutoimmunityHumoral ImmunityDelayed HypersensitivityPharmacologyBovine γ GlobulinImmunosuppressive TherapyImmunoglobulin EImmunosuppressionMedicine
Abstract The effects of promethazine-HCl on humoral antibody synthesis and on delayed hypersensitivity have been evaluated. The primary and secondary immune responses to bovine serum albumin (BSA) and bovine γ globulin (BGG) were significantly reduced. There was a highly significant reduction in tuberculin hypersensitivity when the drug was administered before and during the development of the hypersensitive state.