Genomic sequencing and molecular characteristics of a very virulent strain of infectious bursal disease virus isolated in China.

Abstract

[Objective] The paper was to determine the genomic sequence of a very virulent strain of infectious bursal disease virus(IBDV),and study its molecular characteristics.[Method] A very virulent strain(vvIBDV)(HLJ-0504) of infectious bursal disease virus(IBDV) with special characters was isolated in China and its genome was sequenced.[Result] Sequence analysis showed that segment A of HLJ-0504 was derived from vvIBDV,while segment B was from a distinct ancestor.The morbidity and mortality of HLJ-0504 was 100% and 86.7%to SPF chickens,respectively.[Conclusion] vvIBDV with distinct segment B were still circulating and the evolution of IBDV was diversified in China.Besides,it is hard to imagine that the virulence of IBDV is determined solely by segment A or B.